目的:掌握濮阳市出生缺陷的变化趋势,探讨出生缺陷发生的相关因素,为制定和采取预防措施提供依据。方法:按照全国出生缺陷监测方案,对2001年12月1日～2006年11月30日濮阳市4所市直医院、6所县直医院、6所乡镇卫生院的29814例围产儿出生缺陷进行监测。结果:出生缺陷发生率为8.12‰,出生缺陷的发生与孕母的年龄、孕龄、胎次、职业、居住环境、是否婚检、是否参加围产期保健等因素有关。结论:降低出生缺陷发生率应采取以下措施:做好计划生育工作,加强婚前保健及围产期保健工作,避免孕早期患病,营造孕期良好环境,广泛开展健康教育,育龄妇女增补叶酸,进一步加强出生缺陷监测工作,制定有效的干预措施。 OBJECTIVE: To grasp the changing trend of birth defects in Puyang City, to explore the related factors of birth defects, and to provide the basis for making and adopting preventive measures. Methods: According to the national birth defects monitoring program, the 29814 cases of perinatal birth defects in 4 municipal hospitals, 6 county hospitals and 6 township hospitals in Puyang from December 1, 2001 to November 30, 2006 were monitored . Results: The incidence of birth defects was 8.12 ‰. The incidence of birth defects was related to the age, gestational age, parity, occupation, living environment, premarital examination, whether or not to participate in perinatal care and other factors. Conclusions: The following measures should be taken to reduce the incidence of birth defects: to do a good job of family planning work, to strengthen premarital health and perinatal health care, to avoid premature pregnancy, to create a good environment during pregnancy, to carry out extensive health education, to add folic acid to women of childbearing age, Strengthen the monitoring of birth defects and formulate effective interventions.