目的探讨中晚期鼻咽癌常规分次放疗联合同步化疗患者预后的风险因素。方法选择我院2006年01~12月常规分次放疗联合化疗的中晚期鼻咽癌患者临床资料100例,将患者一般资料、临床资料及影像学资料列为研究因素,建立COX生存风险比例模型,分析影响患者生存的相关因素及风险因素。结果单因素筛选结果显示:肿瘤分期、侵犯器官数目、规律放疗与否、规律化疗与否、早期复发是影响预后的相关因素。COX分析结果显示:规律放疗与否、规律化疗与否、早期复发及肿瘤侵犯器官数目是常规分次放疗联合同步化疗中晚期鼻咽癌患生存风险因素。结论中晚期鼻咽癌常规分次放疗联合同步化疗患者的预后与肿瘤的进展及放化疗的实施情况相关,应加强早期诊断及规律治疗。 Objective To investigate the risk factors of prognosis in patients with advanced nasopharyngeal carcinoma treated by conventional fractionated radiotherapy combined with concurrent chemotherapy. Methods The clinical data of 100 patients with advanced NPC treated by conventional fractionated radiotherapy and chemotherapy from January 2006 to December 2006 in our hospital were selected. The general data, clinical data and imaging data were used as the researching factors to establish the COX survival risk proportional model , Analyze the factors that affect the survival of patients and risk factors. Results The results of single factor screening showed that the related factors of prognosis were tumor staging, number of organ invasion, regular radiotherapy or not, regular chemotherapy or early recurrence. The results of COX analysis showed that regular radiotherapy or not, regular chemotherapy or not, early recurrence and the number of tumor invasion organ were the risk factors for survival of patients with advanced nasopharyngeal carcinoma in conventional fractionated radiotherapy combined with concurrent chemotherapy. Conclusions The prognosis of patients with advanced nasopharyngeal carcinoma treated by conventional fractionated radiotherapy combined with concurrent chemotherapy is related to the progress of the tumor and the implementation of radiotherapy and chemotherapy. Early diagnosis and regular treatment should be strengthened.