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[目的]探讨大剂量奥美拉唑对老年胃溃疡合并出血患者在再出血的影响。[方法]86例老年胃体溃疡并出血患者分成两组,实验组应用大剂量奥美拉唑持续给药:首次80mg静脉推注,然后以8mg/h的速度持续72h;对照组静脉滴注奥美拉唑每12h1次,每次40mg。应用3d,然后口服奥美拉唑,每日1次,每次20mg,疗程均为1个月,观察两组患者3d和30d再出血率并进行比较。[结果]实验组有3例在3d内再出血,发生率为6.98,而对照组有8例,占18.6,两者比较差异有统计学意义(P﹤0.05)。在30d再出血的情况中,实验组无1例出现,为0,而对照组中有2例出现,占4.65,两者比较差异有统计学意义(P﹤0.05)。[结论]大剂量奥美拉唑治疗在预防老年胃溃疡合并出血患者的近期、远期再出血方面具有积极的治疗作用,可以达到很好的治疗效果,值得在临床广泛应用。
[Objective] To investigate the effect of high-dose omeprazole on rebleeding in elderly patients with gastric ulcer combined with hemorrhage. [Method] Eighty-six elderly patients with gastric ulcer and bleeding were divided into two groups. The experimental group was orally administered with high-dose omeprazole for the first time: 80mg intravenous injection for 8 months and then for 72 hours. In the control group, intravenous infusion Omeprazole every 12h1 times, each 40mg. Application of 3d, and then oral omeprazole, 1 day, each 20mg, treatment were 1 month, two groups of patients 3d and 30d rebleeding rate and compared. [Results] In the experimental group, 3 patients rebleeded within 3 days, the incidence was 6.98, while the control group had 8 cases, accounting for 18.6. The difference was statistically significant (P <0.05). In the case of rebleeding after 30 days, none of the cases in the experimental group appeared as 0, while in the control group, 2 cases appeared, accounting for 4.65. The difference between the two groups was statistically significant (P <0.05). [Conclusion] The high-dose omeprazole treatment has a positive therapeutic effect in the prevention of short-term and long-term hemorrhage in elderly patients with gastric ulcer combined with bleeding, which can achieve good therapeutic effect and is worth widely used in clinical practice.