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目的探讨复合性淋巴瘤(CL)的病理组织学特征、诊断与发病机制。方法应用光镜观察及免疫组化染色对3例少见类型的CL进行临床病理学分析。结果 3例CL中2例为转化的弥漫性大B细胞淋巴瘤(DLBCL),其中1例由慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL)转化为DLBCL(Richter综合征);另1例为结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)转化为DLBCL;第3例为原发性纵隔大B细胞淋巴瘤(PMBCL)合并经典型霍奇金淋巴瘤(cHL)。结论 CL是一种特殊类型淋巴瘤。发生转化后的Richter综合征预后差;NLPHL预后较好,但可进展为侵袭性淋巴瘤。非霍奇金淋巴瘤(NHL)与HL的关系密切。
Objective To investigate the pathological features, diagnosis and pathogenesis of complex lymphoma (CL). Methods The clinical and pathological features of 3 rare cases of CL were analyzed by light microscopy and immunohistochemical staining. Results Two cases of CL were transformed into diffuse large B-cell lymphoma (DLBCL), of which 1 was converted from chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL / SLL) to DLBCL (Richter syndrome) One case was nodular lymphocyte predominantly Hodgkin’s lymphoma (NLPHL) which was converted to DLBCL. The third case was primary large mediastinal B-cell lymphoma (PMBCL) combined with classical Hodgkin lymphoma (cHL) . Conclusion CL is a special type of lymphoma. After the conversion of Richter syndrome prognosis is poor; NLPHL prognosis is good, but can progress to invasive lymphoma. Non-Hodgkin’s lymphoma (NHL) is closely related to HL.