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原发性肺癌伴转移的动物模型至今国内外尚未见报道，这对深入研究肺癌转移的机理和开发抗转移新药带来许多困难，是目前急待解决的重点课题之一。近几年来参考有关文献报道［１，２，３］，摸索建立苯并芘诱发小鼠原发性肺癌后，观察并建立了小鼠原发性肺癌伴胸腔淋巴结转移的
The animal model of primary lung cancer with metastasis has not been reported at home and abroad, which has brought about many difficulties for the in-depth study of the mechanism of lung cancer metastasis and the development of anti-metastatic drugs. It is one of the key issues to be solved at present. In recent years, with reference to relevant literature reports [1,2,3], exploring the establishment of benzopyrene-induced primary lung cancer in mice, observed and established primary lung cancer with thoracic lymph node metastasis in mice.