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我院在1983年内科住院病人中曾有3例,因服左旋咪唑而引起严重的毒副反应,其中2例畏寒、高热,1例死亡。今报道如下。 例1 林×,(住院号47919)女,31岁,于20天前口服驱虫药6片,次日即发热、头晕,经当地医院治疗7~8天,体温降至正常,头晕亦有改善,但睡眠不佳。入院前3~4天,反复头晕、头痛;入院当天(1983年11月21日)呕吐7~8次。入院检查除头晕、呕吐、粪便中找到钩虫卵外,未见特殊病症。于次日晨8时给左旋咪唑150mg,下午3时即出现头晕、呕吐加剧、伴有寒战、发热、呼吸衰竭(口唇发绀),于11月25日晨心跳停止而死亡。
In our hospital in 1983 medical inpatients had three cases, because of levamisole and cause serious side effects, including two cases of chills, fever, and 1 death. Now reported as follows. Example 1 Lin ×, (hospital number 47919) Female, 31 years old, oral deworming medicine 6 tablets 20 days ago, the next day that is fever, dizziness, the local hospital for 7 to 8 days, the body temperature dropped to normal, dizzy also Better, but poor sleep. 3 to 4 days before admission, dizziness, headache; on the day of admission (November 21, 1983) vomiting 7 to 8 times. Admission except for dizziness, vomiting, stool found in hookworm eggs, no special conditions. Levamisole 150 mg was given at 8 a.m. on the morning of the following day and dizziness and vomiting were exacerbated at 3 pm with chills, fever and respiratory failure (cyanosis of the lips), and died on the morning of November 25 when her heartbeat stopped.