论文部分内容阅读
目的探讨乳腺癌中Foxp3+调节性T细胞浸润的意义。方法免疫组织化学方法检测46例浸润性乳腺癌癌组织中Foxp3+调节性T细胞和CD8+细胞毒性T细胞的浸润。每个病例分别计数5个高倍视野中浸润细胞的数量并计算平均值,以中位数区分高密度和低密度浸润并比较与临床病理特征之间的关系。结果多数病例中两型T细胞以瘤周浸润为特点。每个高倍视野,Foxp3+T细胞中位数为24.7个,CD8+T细胞为67.4个。Foxp3+T细胞浸润数量与乳腺癌病理组织学分级显著相关(P<0.01),而CD8+T细胞浸润数量与各临床病理参数无关。结论肿瘤浸润性Foxp3+T细胞的数量为乳腺癌潜在的预后指标。
Objective To investigate the significance of Foxp3 + regulatory T cell infiltration in breast cancer. Methods The infiltration of Foxp3 + regulatory T cells and CD8 + cytotoxic T lymphocytes in 46 invasive breast cancer tissues was detected by immunohistochemistry. In each case, the number of infiltrating cells in five high power fields was counted and averaged, and the high and low density infiltration was distinguished by median and the relationship with clinicopathological features was compared. Results In most cases, two types of T cells were characterized by perivascular infiltration. At each high power field, Foxp3 + T cells had a median of 24.7 and CD8 + T cells 67.4. The number of Foxp3 + T cells was significantly correlated with the pathological grade of breast cancer (P <0.01), while the number of infiltrating CD8 + T cells was not related to the clinicopathological parameters. Conclusions The number of tumor-infiltrating Foxp3 + T cells is a potential prognostic indicator for breast cancer.