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目的 探讨广州铁路系统职工消化性溃疡（ Ｐ Ｕ）临床特点与年度变化的规律。方法 将 １９８５ 年（１０５例）、１９９５ 年（１９９ 例）确诊为 Ｐ Ｕ 的住院病例逐月统计比较，幽门螺杆菌（ Ｈ Ｐ）以 Ｇｉｍ ｅｓａ 法检测。结果 ①两年流行病学资料符合 Ｐ Ｕ 发病一般规律（ Ｐ ＞ ００５），但 １０ 月份 Ｐ Ｕ 病例数较高（ Ｐ ＜ ００５）。②１９９５ 比 １９８５ 年并发穿孔减少、出血增多（ Ｐ ＜ ００１）。内科治疗数增多、手术数减少（ Ｐ ＜ ００１）（ ｒ ＝ － １）。③抑酸治疗复发率、再出血率高于根除 Ｈ Ｐ治疗组（ Ｐ ＜ ００１）。结论 ①加强心理保健是预防 Ｐ Ｕ 及并发症的措施之一。②抑酸剂治疗不失为保守治疗的有效药物。③根除 Ｈ Ｐ可有效提高 Ｐ Ｕ 治愈率、降低复发率和再出血率。
Objective To investigate the clinical characteristics and annual changes of peptic ulcer (P U) in Guangzhou railway system. Methods The monthly comparisons of hospitalized cases with P U diagnosed in 1985 (105 cases) and 1995 cases (199 cases) were compared. The Helicobacter pylori (H P) was detected by Gim esa method. Results ① The epidemiological data of two years accorded with the general rule of P U onset (P> 005), but the number of P U cases was higher in October (P <005). ②1995 than in 1985 decreased perforation, bleeding increased (P <0 01). The number of medical treatment increased, the number of surgery decreased (P <0 01) (r = - 1). ③ acid suppression of the recurrence rate, rebleeding rate higher than the eradication of H P treatment group (P <0 01). Conclusion ① strengthening mental health care is one of the measures to prevent P U and complications. ② Antacid therapy is an effective drug for conservative treatment. ③ eradication of H P can effectively improve the cure rate of P U, reduce the recurrence rate and rebleeding rate.