论文部分内容阅读
目的观察调经促排汤联合克罗米芬(CC)预防黄素化卵泡不破裂综合征(luteinized unrup-ured follicle syndrome,LUFS)的临床疗效。方法将80例LUFS患者随机分为两组。对照组于月经第5天给予口服克罗米芬(CC)50~150 mg/d,共5 d,当主卵泡直径平均≥18 mm时,肌注绒毛膜促性腺激素(h CG)10000 IU,并指导夫妻同房。治疗组在对照组基础上于月经第3天开始口服调经汤,于卵泡发育直径≥18 mm时开始口服促排汤。于月经周期第3天检测血清中雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)的含量;于月经周期第11天开始,行B超监测卵泡发育情况,当优势卵泡直径≥18 mm,测量子宫内膜厚度,检测血清中E2、LH、FSH的含量;统计两组患者再次出现卵泡不破裂的发生率及妊娠率。结果月经第三天治疗组治疗后E2、LH水平与治疗前及对照组比较均有明显改善(P<0.01),卵泡成熟日治疗组治疗后FSH、LH水平与治疗前及对照组比较均有明显改善(P<0.01),治疗组治疗后子宫内膜厚度显著优于对照组(P<0.05),治疗后治疗组卵泡不破裂黄素化发生率少于对照组(P<0.05),治疗组总疗效及妊娠率高于对照组(P<0.01)。结论调经促排汤联合克罗米芬(CC)预防卵泡未破裂黄素化综合征疗效确切。
Objective To observe the clinical curative effect of Tiaojian Tiaozhi Decoction combined with clomiphene citrate (CC) on preventing luteinized unrup-ured follicle syndrome (LUFS). Methods 80 LUFS patients were randomly divided into two groups. The control group received oral clomiphene citrate (CC) 50-150 mg / d on the fifth day of menstruation for 5 days. When the main follicle diameter averaged ≥ 18 mm, the intramuscular chorionic gonadotropin (h CG) was 10000 IU and instructed Couples with the same room. On the basis of the control group, the treatment group started oral administration of Tiaojing Decoction on the 3rd day of menstruation, and started oral administration of Tiaozhi Decoction when the follicular diameter ≥18 mm. Serum estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were detected on the third day of the menstrual cycle. On the 11th day of the menstrual cycle, the development of follicles was monitored by B- Follicle diameter ≥ 18 mm, the thickness of the endometrium was measured, the contents of E2, LH and FSH in the serum were detected; the incidence of follicular non-rupture and the pregnancy rate again were counted in the two groups. Results On the third day after menstruation, the levels of E2 and LH in the treatment group were significantly improved compared with those before treatment and the control group (P <0.01). FSH and LH levels in the mature follicle-treated group were significantly higher than those before treatment and in the control group (P <0.01). The thickness of endometrium in the treatment group was significantly better than that in the control group (P <0.05). After treatment, the incidence of non-ruptured follicles in the treatment group was lower than that in the control group (P <0.05) Efficacy and pregnancy rate was higher than the control group (P <0.01). Conclusion Tiaojingyitao Decoction combined with clomiphene citrate (CC) to prevent follicular unruptured luteinizing syndrome is effective.