目的　探讨氧氟沙星、丁胺卡那、结核清、对氨柳酸钠等组成化疗方案 ,治疗难治性肺结核的效果。方法　对使用该方案治疗的 2 6例难治性肺结核的治疗效果进行分析。结果　 2 6例患者经 9个月的治疗痰菌阴转率为 84 .6% ,空洞缩小或闭合率为 57.1%。停药后观察 ,一年痰菌复发率为 4 .5%。结论　该方案治疗难治性肺结核疗效显著、复发率低。 Objective To investigate the effect of ofloxacin, amikacin, tuberculosis and sodium salicylate in the treatment of refractory pulmonary tuberculosis. Methods The therapeutic effect of 26 cases of refractory pulmonary tuberculosis treated with this regimen was analyzed. Results 26 cases of patients after 9 months of treatment sputum negative conversion rate of 84.6%, cavity shrinkage or closure rate of 57.1%. After stopping the observation, one year sputum bacterial recurrence rate was 4.5%. Conclusion The treatment of refractory tuberculosis has significant curative effect and low recurrence rate.