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2-Oxo-butyric acid salicylacylhydrazone dibenzyltin(IV) complexes 1 {[o-OHC_6H_4(O)C=N-N=C(Et)COO](CH_3OH)[(C_6H_5CH_2)_2Sn]}_2 and 2 {[o-OH-C_6H_4(O)C=N-N=C(Et)-COO](CH_3OH)[(2,4-Cl_2C_6H_3CH_2)_2Sn]}_2 have been synthesized. The complexes were characterized by IR, ~1H, ~(13)C and ~(119)Sn NMR spectra, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex 1 belongs to triclinic system, space group P1 with a = 8.9121(6), b = 10.3875(7), c = 14.5658(10) ?, α = 89.534(5), β = 86.790(5), γ = 70.103(6)°, Z = 1, V = 1265.85(15) ?3, Dc = 1.488 Mg·m~(-3), m(Mo Kα) = 1.047 mm-1, F(000) = 576, R = 0.0466 and w R = 0.1054. The crystal of complex 2 belongs to monoclinic system, space group P21/n, a = 12.7165(10), b = 17.8466(14), c = 12.8538(10) ?, β = 95.1310(10)°, Z = 2, V = 2905.4(4) ?~3, Dc = 1.612 Mg·m~(-3), m(Mo Kα) = 1.286 mm-1, F(000) = 1408, R = 0.0369 and w R = 0.0958. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay against three human cancer cell lines(NCI-H460, HepG2, MCF7) and one human cell line(HL7702). Two complexes exhibited strong antitumor activity, and then they were expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe. The interactions of the two complexes with calf thymus DNA were intercalation.
2-Oxo-butyric acid salicylacylhydrazone dibenzyltin (IV) complexes 1 {[o-OHC_6H_4 (O) C = NN = C (Et) COO] (CH_3OH) [C_6H_5CH_2) _2Sn] C_6H_4 (O) C = NN = C (Et) -COO] (CH_3OH) [(2,4-Cl_2C_6H_3CH_2) _2Sn]} 2 has been synthesized. The crystal of complex 1 belongs to triclinic system, space group P1 with a = 8.9121 (6), b = Α = 89.534 (5), β = 86.790 (5), γ = 70.103 (6) °, Z = 1 and V = 1265.85 (15) 1.488 Mg · m -3, m (Mo Kα) = 1.047 mm -1, F (000) = 576, R = 0.0466 and w R = 0.1054. The crystal of complex 2 belongs to monoclinic system, space group P21 a = 12.7165 (10), b = 17.8466 (14), c = 12.8538 (10), β = 95.1310 (10) °, Z = 2, V = 2905.4 Mg (m) -3, m (Mo Kα) = 1.286 mm -1, F (000) = 1408, R = 0.0369 and w R = 0.0958. In vitro antitumor activation ities of both complexes were evaluated by the 3- (4,5-dimethylthiazoly-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460, HepG2, MCF7) The interactions between complexes and calf thymus DNA were studied by EB fluorescent probe. The interactions of the the two complexes with calf thymus DNA were intercalation.