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目的:观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)和氟尿嘧啶(5-Fu)治疗晚期胃癌的疗效和毒副反应。方法:33例晚期胃癌患者,静脉滴注奥沙利铂130 mg/m2,第1天;亚叶酸钙200 mg,第1~5天,氟尿嘧啶300mg/m2第1~5天;21或28天为1周期。进行3周期后评价疗效。结果:完全有效(CR)2例,部分有效(PR)14例,稳定(SD)10例,进展(PD)7例,近期有效率(CR+PR)48.4%。结论:奥沙利铂联合CF/5-Fu方案疗效较高,毒副反应轻,耐受性好。
Objective: To observe the efficacy and toxicity of oxaliplatin (L-OHP) combined with leucovorin (CF) and fluorouracil (5-Fu) in the treatment of advanced gastric cancer. METHODS: Thirty-three patients with advanced gastric cancer received intravenous infusion of oxaliplatin 130 mg/m2 on the first day; leucovorin 200 mg on days 1-5; fluorouracil 300 mg/m2 on days 1-5; 21 or 28 days. It is 1 cycle. The efficacy was evaluated after 3 cycles. RESULTS: There were 2 cases of complete response (CR), 14 cases of partial response (PR), 10 cases of stable (SD), 7 cases of progressive (PD), and 48.4% of recent effective rate (CR+PR). Conclusion: Oxaliplatin combined with CF/5-Fu has a high curative effect, mild side effects and good tolerability.