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家兔静脉注射吡喹酮35～45mg/kg后10分钟内,80.9％(17/21)的兔发生心律失常,持续1～21分钟后恢复窦性心律。心律失常出现前心率较正常时缓慢的占84.1％(58/69)。抗心律失常药中,以酚苄明3mg/kg对抗吡喹酮所致心律失常转为窦性心律的作用最好,其次为氯丙嗪(5mg/kg)、异搏停(0.3～0.5mg/kg)、异丙嗪(3～5mg/kg)及苯妥因钠(50mg/kg),利多卡因、奎尼丁、异丙肾上腺素与阿托品等有部分或作用不完全的抗心律失常的效果。心得宁与常咯啉则无效。先给兔注射苯妥因钠(50mg/kg)或氯丙嗪(5mg/kg)等,有较好的防止吡喹酮所致心律失常的作用。
Within 10 minutes after intravenous injection of praziquantel 35 ~ 45mg / kg in rabbits, 80.9% (17/21) of the rabbits developed arrhythmia and returned to sinus rhythm after 1 ~ 21 minutes. Heart rate before arrhythmia than normal slow accounted for 84.1% (58/69). Antiarrhythmic drugs, phenoxybenzamine 3mg / kg anti-praziquantel-induced arrhythmia into sinus rhythm best, followed by chlorpromazine (5mg / kg), verapamil (0.3 ~ 0.5mg / kg), promethazine (3 ~ 5mg / kg) and phenytoin sodium (50mg / kg), lidocaine, quinidine, isoproterenol and atropine, etc. have some or incomplete anti-arrhythmia Effect. Experience Ning and regular pyrroline is invalid. Rabbit injection of phenytoin sodium (50mg / kg) or chlorpromazine (5mg / kg), etc., have better anti-praziquantel-induced arrhythmias.