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随着传统化疗、干扰素及干细胞移植的发展,多发性骨髓瘤的治疗取得了很大进步,但仍存在耐药及易复发等问题。为了进一步改善骨髓瘤患者的预后,在分子水平治疗方面出现了一些新的策略, 如以骨髓新生血管、细胞表面受体、骨髓瘤细胞DNA分子作为靶点,促进骨髓瘤细胞的凋亡,调节骨髓微环境,或是调节骨髓微环境与骨髓瘤细胞间的相互作用。这些新的治疗方法在临床及动物试验中已取得一定疗效。
With the development of traditional chemotherapy, interferon and stem cell transplantation, the treatment of multiple myeloma has made great progress, but there are still some problems such as drug resistance and relapse. In order to further improve the prognosis of patients with myeloma, there are some new strategies in the molecular level of treatment, such as bone marrow neovascularization, cell surface receptors, myeloma cells DNA molecules as a target, promote myeloma cell apoptosis, regulation Bone marrow microenvironment, or regulate the interaction between the bone marrow microenvironment and myeloma cells. These new treatments have achieved some efficacy in clinical and animal experiments.