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目的从改善微循环角度评价止痛一号方联合羟苯磺酸钙与甲钴胺治疗三叉神经痛的临床疗效。方法将98例患者随机分为治疗组和对照组。治疗组50例予中药止痛一号方联合羟苯磺酸钙与甲钴胺;对照组48例予卡马西平加甲钴胺;两组疗程均为8周,观察临床疗效及VAS评分变化情况。结果治疗组、对照组总有效率分别为86.0%、68.8%,治疗组临床疗效优于对照组(P<0.05)。两组VAS评分在治疗后均明显下降(P<0.05),组间治疗后差异有统计学意义(P<0.05)。治疗组不良反应发生率为12.0%,明显低于对照组的31.25%(P<0.05)。结论止痛一号方联合羟苯磺酸钙与甲钴胺治疗三叉神经痛安全、有效。
Objective To evaluate the clinical effect of Zhitong Yihou Fang combined with calcium dobesilate and mecobalamin in the treatment of trigeminal neuralgia from the perspective of improving microcirculation. Methods 98 patients were randomly divided into treatment group and control group. Fifty cases in the treatment group were treated with the combination of Chinese medicine Zhitong No.1 with calcium dobesilate and 48 cases in the control group with carbamazepine plus mecobalamin. The course of treatment was 8 weeks. The clinical curative effect and VAS score were observed . Results The total effective rates of the treatment group and the control group were 86.0% and 68.8%, respectively. The clinical efficacy of the treatment group was better than that of the control group (P <0.05). The VAS scores of both groups were significantly decreased after treatment (P <0.05), and there was significant difference between the two groups after treatment (P <0.05). The incidence of adverse reactions in the treatment group was 12.0%, which was significantly lower than that in the control group (31.25%, P <0.05). Conclusion Analgesia No.1 and calcium dobesilate are safe and effective in treating trigeminal neuralgia.