前言 加压呼吸(PPB)是用来增加重力加速度耐受性和在低氧环境中维持动脉血的氧合作用。PPB被认为能引起呼吸过度,这被归因为增加通气而对假定的死腔的补偿。本研究的设计是为了调查PPB引起的血液动力学改变,并通过V_A/Q的匹配的正规评估,来阐明呼吸过度的机理。方法 10名男性健康志愿者插入肺动脉、挠动脉和中心静脉导管。在海平面水平和24900h模拟高度,受试者暴露于COMBATEDGE产 Introduction Pressure breathing (PPB) is used to increase gravitational acceleration tolerance and maintain arterial oxygenation in hypoxic environments. PPB is thought to cause hyperventilation, which is attributed to the increased ventilation that compensates for the assumed dead space. This study was designed to investigate the PPB-induced hemodynamic changes and to elucidate the mechanism of hyperpnea through a formal assessment of the matching of V_A / Q. Methods Ten male healthy volunteers were instrumented into the pulmonary artery, the flexible artery and the central venous catheter. At sea level and simulated altitude of 24900 h, subjects were exposed to COMBATEDGE production