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目的观察 7-氯苄基四氢巴马汀 ( 7-chlor -BTHP)对大鼠心肌肥厚和心室肌原纤维质膜Ca2 + -Mg2 + -ATP酶活力的影响。方法用L -甲状腺素诱发大鼠心肌肥厚 ,然后观察 7-chlor -BTHP对大鼠心肌肥厚及左心室肌原纤维Ca2 + -Mg2 + -ATPase的影响 ,以普萘洛尔 (Pro)作为阳性对照。结果经过 7-chlor-BTHP治疗 3天后 ,心肌肥厚明显改善 ,Ca2 + -Mg2 + -ATPase活力明显降低。结论 7-chlor-BTHP能明显消退L -甲状腺素诱发的大鼠心肌肥厚 ,并能显著降低心室肌原纤维膜Ca2 + -Mg2 + -ATPase酶活力。
Objective To observe the effect of 7-chlor-BTHP on cardiac hypertrophy and Ca2 + -Mg2 + -ATPase activity in ventricular myocytes of rats. Methods Cardiac hypertrophy was induced by L - thyroxine in rats. The effects of 7 - chlor - BTHP on cardiac hypertrophy and Ca2 + -Mg2 + -ATPase in left ventricular myocytes were observed. Propranolol (Pro) Control. Results After 3 days treatment with 7-chlor-BTHP, myocardial hypertrophy was significantly improved and the activity of Ca2 + -Mg2 + -ATPase was significantly decreased. Conclusion 7-chlor-BTHP can remarkably attenuate cardiac hypertrophy induced by L-thyroxine and significantly decrease the activity of Ca2 + -Mg2 + -ATPase in ventricular myofibroblasts.