本文分析了25例磺脲类有效,28例继发性磺脲类失效的Ⅱ型糖尿病患者的胰岛素分泌功能和胰岛素敏感性指数。结果显示,继发性磺脲类失效的Ⅱ型糖尿病患者胰岛素分泌功能较磺脲类有效的Ⅱ型糖尿病患者明显减退(P<0.05和<0.01)。且继发性磺脲类失效的出现与病程有一定的关系。两组间的胰岛素敏感性指数无明显差异(P>0.05)。表明在继发性磺脲类失效的Ⅱ型糖尿病患者中存在胰岛β细胞功能的减退,应及时应用胰岛素治疗。 This article analyzes the 25 cases of sulfonylurea effective, 28 cases of secondary sulfonylurea failure of type 2 diabetes insulin secretion and insulin sensitivity index. The results showed that insulin secretion in patients with secondary sulfonylurea failure of type II diabetes mellitus was significantly lower than that of sulfonylureas patients with type 2 diabetes (P <0.05 and <0.01). Secondary sulfonylurea failure and the emergence of a certain relationship. Insulin sensitivity index between the two groups showed no significant difference (P> 0.05). Show that in the secondary failure of sulfonylurea type Ⅱ diabetes, there is a decline in pancreatic β-cell function, prompt insulin treatment should be applied.