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１９８４年开始在广东省范围内开展地方性氟中毒流行病学调查及防治效果观察。结果广东省２１个地级市１１８个县（市）中有１７个市、４０个县有不同程度的地氟病流行。病区４４８个、病区总人口数为５７６４６７，约占全省总人口的１％。病区主要分布在粤东四个市（汕头、揭阳、潮州、梅州），病区数占全省的５２．７％，病区人口数占８６．９％。病区类型以饮水型为主（９５％），少数为温泉水污染食物型。造成地氟病流行的主要原因是广东境内富氟地质构造中的氟转移到居民饮用水源，引起水氟超标。饮水型病区经改水降氟后，水氟由改水前１２．５ｍｇ／ｌ降至０．３４ｍｇ／ｌ，改水后第七年８～１２岁儿童氟斑牙患病率由改水前９６％降至７３．３％．其尿氟含量（０．９６ｍｇ／ｌ）降至正常值以下。
Epidemiological investigation of endemic fluorosis and its prevention and control were carried out in Guangdong Province in 1984. Results There were 17 cities in 118 prefectures (cities) of 21 prefecture-level cities in Guangdong province, and 40 prefectures had different degrees of endemic fluorosis. 448 wards, ward total population of 576,467, accounting for about 1% of the province’s total population. Ward mainly in four cities in eastern Guangdong (Shantou, Jieyang, Chaozhou, Meizhou), the number of ward accounted for 52.7% of the province, ward population accounted for 86.9%. The ward type mainly drinking water (95%), a small number of hot spring water pollution food type. The main reason for the endemic fluorosis is that the fluorine in the fluorite geological structure in Guangdong is transferred to drinking water source of residents, causing excessive fluoride in water. Drinking water-based ward after the water fluoride, the water fluoride from the water before 12.5mg / l dropped to 0.34mg / l, after the water change in the seventh year of 8 to 12-year-old children dental fluorosis increased from water The first 96% dropped to 73.3%. The urinary fluoride content (0.96mg / l) fell below the normal value.