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目的:观察分析甲泼尼龙联合免疫球蛋白治疗急性脊髓炎的临床治疗效果。方法:从2011年6月-2014年7月丽江市人民医院收治的急性脊髓炎患者中随机抽取100例作为研究对象,根据治疗方案和患者意愿分成对照组和观察组,各50例。其中对照组单纯使用甲泼尼龙进行治疗,观察组在对照组的基础上使用免疫球蛋白进行联合治疗,对两组的治疗效果、恢复时间、ASIA评分和不良反应等指标进行比较。结果:观察组的治疗总有效率为92%,显著高于对照组的80%,差异具有统计学意义(P<0.05)。观察组的恢复时间、美国脊髓损伤学会(ASIA)评分均优于对照组,差异具有统计学意义(P<0.05)。两组都出现3例不良反应,差异无统计学意义(P>0.05)。结论:对急性脊髓炎患者使用甲泼尼龙和免疫球蛋白进行联合治疗可以显著提高临床治疗效果,缩短恢复时间,促进患者的神经功能评分。
Objective: To observe and analyze the clinical effect of methylprednisolone combined with immunoglobulin in the treatment of acute myelitis. Methods: From June 2011 to July 2014, 100 cases of acute myelitis patients admitted to Lijiang People’s Hospital were randomly selected as the research object. According to the treatment plan and the patients’ wishes, the patients were divided into control group and observation group, 50 cases each. The control group was treated with methylprednisolone only. The observation group was treated with immunoglobulin on the basis of the control group, and the treatment effect, recovery time, ASIA score and adverse reaction were compared between the two groups. Results: The total effective rate of the observation group was 92%, which was significantly higher than that of the control group (80%), the difference was statistically significant (P <0.05). Recovery time of the observation group, American Society of Spinal Cord Injury (ASIA) score were better than the control group, the difference was statistically significant (P <0.05). There were 3 adverse reactions in both groups, the difference was not statistically significant (P> 0.05). Conclusion: The combination of methylprednisolone and immunoglobulin in patients with acute myelitis can significantly improve the clinical effect, shorten the recovery time and promote the neurological score of patients.