甲型肝炎病毒(HAV)颗粒具有单股正链RNA基因组。以往进行的HAV体内增殖试验所用宿主多局限在非人灵长类。为了将HAV感染的动物模型扩展到常规动物,作者对HAV在已建成的鼠细胞系中的生长进行了进一步研究。试验材料主要是小鼠细胞系L929、Balb/3T3 cloneA31、NIH/3T3以及Swiss/3T3。病毒株HAV.T.T自甲型肝炎患者粪便分离所得。将HAV用由狷猴肝细胞和 Hepatitis A virus (HAV) particles have a single-stranded positive-stranded RNA genome. Previously performed HAV in vivo proliferation assays were mostly limited to non-human primates. In order to extend animal models of HAV infection to conventional animals, the authors further studied the growth of HAV in established murine cell lines. The experimental materials were mainly mouse cell line L929, Balb / 3T3 cloneA31, NIH / 3T3 and Swiss / 3T3. The virus strain HAV.T.T was isolated from the excrement of hepatitis A patients. Use HAV with tamarin hepatocytes and