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目的研究低发区ＰＨＣ患者ＨＢＶ感染、家族肝癌史及与ＡＢＯ血型的关系。方法５１０例ＰＨＣ按照患者籍贯、ＨＢＶ感染、家族肝癌史及ＡＢＯ血型进行分组，以卡方检验进行统计学处理。结果１、肝癌低发区与高发区一样，合并ＨＢＶ感染的ＰＨＣ患者达８０．７４％，远多于无ＨＢＶ感染者；男性多于女性；有家族肝癌史的ＰＨＣ患者占４０．００％，且合并ＨＢＶ感染的ＰＨＣ有家族肝癌史者远多于ＨＢＶ阴性组（Ｐ＜０．０５）。２、低发区ＰＨＣ中，有家族肝癌史的Ａ型血者显著多于相应对照相（Ｐ＜０．０５）。结论我国肝癌低发区ＰＨＣ发生的最重要外因亦为ＨＢＶ感染，遗传易感性则是其内因；而有ＨＢＶ感染或有家族肝癌史者是ＰＨＣ的高危人群，且后者中的Ａ型血者更为易患，对这一人群需加强监测，警惕ＰＨＣ的发生
Objective To investigate the relationship between HBV infection, family HCC history and ABO blood type in PHC patients with low incidence area. Methods 510 cases of PHC were grouped according to the patient’s origin, HBV infection, history of family HCC and ABO blood group. The chi-square test was used for statistical analysis. Results 1. In the low-risk area of HCC, as in the high-risk area, PHC patients with HBV infection reached 80.74%, far more than those without HBV infection; more men than women; PHC patients with a history of family HCC accounted for 40.00%. There were more family history of hepatocellular carcinoma in HBV-infected PHC than in HBV-negative group (P<0.05). 2. In the low-incidence area PHC, the type A blood with family history of hepatocellular carcinoma was significantly more than the corresponding control (P<0.05). Conclusions The most important external cause of PHC in low incidence areas of liver cancer in China is also HBV infection, genetic susceptibility is its internal cause; while patients with HBV infection or family history of liver cancer are high risk population of PHC, and in the latter type of A blood type More vulnerable to the need for this group of people need to strengthen monitoring, alert PHC