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目的观察10味平性药和5味寒性药对血淤证大鼠肠系膜微循环的影响。方法灌胃给药,14 d,末次药后1 h,麻醉,除正常组外,其余各组尾静脉注射内毒素6 mg/kg,90 min后,观察各组大鼠肠系膜的血流速度、血管管径、毛细血管网交点计数。结果与模型组比较,10味平性药组和5味寒性药组均可提高微循环血流速度(P<0.01);除平性药蒲黄低剂量组外,其余各平性药组和寒性药组均可增加网交数(P<0.05或P<0.01);平性药桃仁、苏木、银杏叶、血竭、三棱、王不留行、蒲黄高剂量组、合欢皮低剂量组及寒性药大黄和丹参均可扩张微血管管径(P<0.05或0.01)。结论对内毒素所致微循环障碍的作用,10味平性药和5味寒性药均可提高微循环血流速度并增加网交数;平性药桃仁、苏木、银杏叶、血竭、三棱、王不留行、蒲黄、合欢皮及寒性药大黄和丹参可扩张微血管管径。
Objective To observe the effects of 10-flavorant and 5-flavonoid drugs on mesenteric microcirculation in blood-stasis syndrome rats. Methods The rats were anesthetized by intragastric administration for 14 days and 1 hour after the last dose. Except the normal group, the rats in each group were injected endotoxin 6 mg / kg into the caudal vein for 90 min, then the mesenteric blood flow velocity, Blood vessel diameter, capillary network intersection count. Results Compared with the model group, both 10-ping-ping drug group and 5-drug-cold drug group could improve microcirculation blood flow velocity (P <0.01) (P <0.05 or P <0.01). The results showed that the average number of nosocomial and nocturnal treatment groups were significantly higher than that of the control group (P <0.05 or P <0.01) Low-dose group and cold medicine Rhubarb and Salvia can dilate the diameter of microvessel (P <0.05 or 0.01). Conclusions The effects of endotoxin-induced microcirculation disorder, 10-flavonoid drug and 5-flavonoid drug can increase the microcirculation blood flow velocity and increase the number of nets. , Tri-Prism, the king does not stay line, Puhuang, Albizia and cold drugs Rhubarb and Salvia can expand the diameter of microvessels.