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目的探讨丙型肝炎病毒(hepatitis C virus,HCV)慢性感染者抗F蛋白抗体阳性率的影响因素。方法收集215例抗HCV抗体阳性患者的血清标本,用间接酶联免疫吸附法(enzyme-linked immuno sorbent assay,ELISA)检测血清抗F蛋白抗体,并进行HCV RNA检测和基因分型。结果抗F蛋白抗体阳性率为66.0%(142/215);单因素分析结果显示,年龄20～岁和51～岁间抗F抗体阳性率差异有统计学意义(P<0.001)、是否合并肝硬化的F抗体阳性率差异有统计学意义(P=0.020),而性别、HCV 1b和2型、HCV RNA阳性和阴性抗F抗体阳性率间差异均无统计学意义(均有P>0.05);将年龄和肝硬化纳入Logistic回归模型得出,年龄为51～岁以及合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,OR(95%CI)值分别为3.45(1.56～7.62)和1.35(1.05～1.73)。结论年龄增长、合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,性别、HCV分型及HCV RNA则不会影响。
Objective To investigate the influencing factors of anti-F protein antibody positive rate in patients with chronic hepatitis C virus (HCV) infection. Methods Serum samples from 215 patients with positive anti-HCV antibodies were collected. Anti-F protein antibodies were detected by enzyme-linked immunosorbent assay (ELISA), and HCV RNA was detected and genotyped. Results The positive rate of anti-F antibody was 66.0% (142/215). The results of univariate analysis showed that the positive rate of anti-F antibody between 20 and 51 years of age was significantly different (P <0.001) There was no significant difference in the positive rates of sclerosing F antibody (P = 0.020), gender, HCV 1b and 2, HCV RNA positive and negative anti-F antibody positive rates (all P> 0.05) ; Age and cirrhosis were included in the Logistic regression model, the age of 51 years of age and cirrhosis of the liver will increase the possibility of anti-F protein antibody positive, OR (95% CI) were 3.45 (1.56 ~ 7.62) and 1.35 (1.05 ~ 1.73). Conclusions Age, combined with cirrhosis of the liver may increase the possibility of positive serum anti-F protein antibody. Sex, HCV typing and HCV RNA have no effect.