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将灭滴灵与其它抗生素联合应用，治疗１３１例四肢开放性创伤患者。在术前和术后静脉输入灭滴灵，同时联合应用其它抗生素。术中和术后换药时亦可用灭滴灵冲洗伤口。１３１例患者术后４例发生感染，无一例厌氧菌感染，感染率为３．１％。未用灭滴灵的１０３例患者，术后１２例发生感染，其中２例厌氧菌感染，感染率为１１％。两组患者的年龄、性别、受伤时间、创伤程度，均无显著性差异（Ｐ＞０．０５），而感染率有显著性差异（Ｐ＜０．０１）。作者认为，灭滴灵对厌氧菌高度敏感；副作用小，且与其它抗生素有协同作用。合理使用灭滴灵可以降低骨创伤术后感染的发生。
Metronidazole and other antibiotics in combination, the treatment of 131 cases of open limb trauma patients. Premedication and postoperative intravenous metronidazole, combined with the application of other antibiotics. Intraoperative and postoperative dressing also available metronidazole wash the wound. In 131 cases, 4 cases were infected with anaerobic bacteria, with an infection rate of 3.1%. In 103 patients who did not receive metronidazole, 12 patients developed infection after the operation, of which 2 were anaerobic infections with an infection rate of 11%. There was no significant difference in age, sex, duration of injury and degree of trauma between the two groups (P> 0.05), but the infection rate was significantly different (P <0.01). The authors believe that metronidazole is highly sensitive to anaerobic bacteria; its side effects are small and synergistic with other antibiotics. Rational use of metronidazole can reduce the incidence of post-traumatic infection.