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目的:目的:研究乙肝疫苗接种对于儿童乙肝病毒(HBV)感染的控制效果。方法:选取2014年1月至2015年10月在该中心接种乙肝病毒的儿童300例,观察其接种1个月后的免疫应答效果。结果:300例儿童中,156例(52.00%)高免疫应答,113例(37.67%)低免疫应答,31例(10.33%)无免疫应答,总免疫应答率为89.67%(269/300);随着年龄的增长,免疫应答有效率及免疫应答强度呈逐渐下降趋势,且<3岁儿童的高免疫应答率及总免疫应答有效率均显著高于5~8岁儿童(P<0.05)。结论:乙肝疫苗接种有利于控制儿童HBV感染率,但疫苗所介导的应答量存在年龄相关性,年龄升高免疫应答将逐渐降低,保护效果也相应降低,宜尽早接受乙肝疫苗接种。
Objective: To study the control effect of hepatitis B vaccination on children’s hepatitis B virus (HBV) infection. Methods: From January 2014 to October 2015, 300 children with HBV inoculated in the center were selected to observe the effect of immune response one month after inoculation. Results: Among 300 children, 156 (52.00%) had high immune response, 113 (37.67%) had low immune response, 31 (10.33%) had no immune response, and the total immune response rate was 89.67% (269/300). With the increase of age, the effective rate of immune response and the intensity of immune response decreased gradually, and the high immune response rate and total effective immune response rate of children <3 years old were significantly higher than those of children aged 5 ~ 8 years (P <0.05). Conclusion: Hepatitis B vaccination is helpful to control the HBV infection rate in children. However, the vaccine-mediated response has an age-related relationship. As the age increases, the immune response will gradually decrease and the protective effect will be reduced correspondingly. Hepatitis B vaccination should be carried out as soon as possible.