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1990年8月至1993年4月,施行同种异体大血管移植治疗小儿复杂先天性心脏病5例,死亡1例.5例中男4例女1例,年龄4-8岁,平均体重18Kg,均为复杂畸形,4例严重紫绀,1例轻度紫绀,病理改变主要在肺动脉系统,病种包括肺动脉闭锁、共同动脉干、右肺动脉起源异常、单心室、大动脉转位等,病种包括肺动脉闭锁、共同动脉干、右肺动脉起源异常、单心室、大动脉转位等.均在深低温低流量或深低温停循环下行根治手术,术式包括Rastelli’s、Fontan’s和肺动脉重建.所用同种血管有带瓣主动脉、带瓣肺动脉及胸主动脉,术后4例恢复良好,无并发症,痊愈出院.1例因严重低心排、肾衰死亡.术后短期随访表明同种异体血管血液动力学良好,瓣膜功能正常,免疫指标正常,无明显排斥反应.
August 1990 to April 1993, the implementation of allogeneic vascular grafts in children with complex congenital heart disease in 5 cases, 1 died. 5 males and 4 females in 1 case, aged 4-8 years, mean body weight 18Kg, are complex deformities, 4 cases of severe cyanosis, 1 case of mild cyanosis, pathological changes mainly in the pulmonary artery system, including pulmonary atresia disease common Arterial stem, right pulmonary artery origin, single ventricle, aortic transposition, etc., including pulmonary atresia, common artery, right pulmonary artery origin, single ventricle, aortic transposition and so on. Radical surgery was performed in deep hypothermia, low-flow or deep hypothermic circulatory arrest, including Rastelli’s, Fontan’s, and pulmonary remodeling. The same type of blood vessels with aortic valve flap, pulmonary valve and thoracic aortic valve, 4 cases recovered well, no complications, discharged. 1 case of severe low cardiac output, renal failure. Short-term follow-up showed that allogeneic blood vessels with good hemodynamics, normal valve function, normal immune indicators, no significant rejection.