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目的观察131Ⅰ治疗甲状腺功能亢进(甲亢)伴有肝功能损害患者的甲状腺及肝功能的转归情况。方法 将143例甲亢患者分成两组:甲亢无肝功能损害组(A组,n=51)及甲亢合并有肝功能损害(B组,n=92)。根据患者相关情况给予适量的131Ⅰ剂量。定期复诊,评价其治疗效果。结果 服131Ⅰ治疗后3个月和6个月,甲亢治愈率分别为69.23％和82.52％,总有效率分别为93.01％和96.50％,两组疗效比较差异无显著性(P>0.05);B组患者病情缓解后肝功能恢复正常,治疗阶段无肝功能损害加重现象。结论 用131Ⅰ治疗甲亢合并肝功损害可有效控制甲亢,同时又可缓解肝功损害。
Objective To observe the outcome of thyroid and liver function in 131 Ⅰ treatment of patients with hyperthyroidism and liver dysfunction. Methods 143 patients with hyperthyroidism were divided into two groups: hyperthyroidism without liver damage (group A, n = 51) and hyperthyroidism with liver dysfunction (group B, n = 92). According to the patient to give the appropriate amount of 131I dose. Regular referral, evaluation of the treatment effect. Results The cure rates of hyperthyroidism were 69.23% and 82.52% respectively at 3 months and 6 months after 131 Ⅰ treatment. The total effective rates were 93.01% and 96.50% respectively. There was no significant difference between the two groups (P> 0.05). Group of patients with remission of liver function returned to normal, no increase in the liver damage during treatment. Conclusion 131I treatment of hyperthyroidism with liver damage can effectively control hyperthyroidism, while reducing liver damage.