氮烯唑胺(DTIC)是一种癌症化学治疗的细胞抑制剂,常见的副作用是中性白细胞和血小板减少,恶心,呕吐、轻度肝功能损害和感冒样综合征。自1979年以来,有文献报导用DTIC 治疗后,可发生广泛肝坏死和肝静脉血拴形成导致急性肝衰竭的严重并发症。本文报告4例同样病例,并结合过去报告的病例,对其发病机制作探讨分析。4例均为皮肤恶性黑色素瘤根治术后,用DTIC单药作术后辅助化疗,出现致命的并发症一急性肝衰竭的临床表现和病理改变。第一周期化疗均用单药 Dacarbazine (DTIC) is a cytostatic agent for cancer chemotherapy. Common side effects are neutropenia and thrombocytopenia, nausea, vomiting, mild liver impairment, and cold-like syndrome. Since 1979, there have been reports of extensive treatment of DTIC in the literature that can lead to severe hepatic necrosis and hepatic vein thrombosis leading to serious complications of acute liver failure. This article reports 4 cases of the same cases, combined with past reports of cases, explore its pathogenesis for analysis. 4 cases were all skin malignant melanoma after radical operation, with DTIC single agent for postoperative adjuvant chemotherapy, there is a fatal complication of acute liver failure clinical manifestations and pathological changes. The first cycle of chemotherapy are used single drug