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目的:探讨卷柏对实验性肝损伤大鼠保护作用机理。方法:采用四氯化碳(CCl4)腹腔注射导致大鼠急性肝损伤的动物模型,用岩柏草总黄酮混悬液灌胃给药,并以水飞蓟宾葡甲胺组为实验对照。结果:岩柏草总黄酮能显著地降低CCl4所致大鼠血清中ALT、AST、NO、PGE2和肝组织中MDA的含量;并可使CCl4所致大鼠肝组织中降低的SOD活性升高,改善肝脏组织的病理损伤。结论:岩柏草对CCl4所致大鼠肝损伤具有保护作用,其作用机理可能与降酶、抗脂质过氧化反应、清除自由基、抑制NO过量成生,降低PGE2含量等有关。
Objective: To investigate the protective mechanism of Selaginella on liver injury in rats. Methods: The animal model of acute liver injury caused by intraperitoneal injection of carbon tetrachloride (CCl4) in rats was administrated intragastrically with the total flavonoids of kobuktusa, and the control group was treated with silybin. Results: The total flavonoids of A. japonica could significantly reduce the contents of ALT, AST, NO, PGE2 and the content of MDA in the liver of CCl4-induced rats, and the activity of SOD in the liver of CCl4-induced rats decreased , To improve the pathological damage of liver tissue. CONCLUSION: Iwakura protective effect of CCl4-induced liver injury in rats, its mechanism may be associated with the reduction of enzymes, anti-lipid peroxidation, scavenging free radicals, inhibition of NO overproduction, reduce PGE2 content.