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目的 研究西红花酸对大鼠实验性动脉粥样硬化的影响。方法 采用给予大剂量维生素 D2 ( VD2 )后饲喂高胆固醇饲料诱发大鼠实验性动脉粥样硬化模型 ,测定大鼠血清总胆固醇 ( TC)、甘油三酯 ( TG)、低密度脂蛋白( L DL- C)、高密度脂蛋白 ( HDL- C)、丙二醛 ( MDA)含量和超氧化物歧化酶 ( SOD)活性。取主动脉和肝脏做病理切片检查。结果 高、低剂量的西红花酸能显著降低动脉粥样硬化大鼠血清 TC、L DL - C和 MDA含量 ;显著升高血清 HDL- C含量、SOD活性和抗动脉粥样硬化指数 ( AAI)。病理切片结果表明 ,西红花酸能明显减轻模型大鼠动脉粥样硬化性损伤。结论 西红花酸具有显著的抗大鼠实验性动脉粥样硬化作用。
Objective To study the effect of crocetin on experimental atherosclerosis in rats. METHODS: Rat model of experimental atherosclerosis induced by high-dose vitamin D2 (VD2) supplemented with high cholesterol diet was used to measure serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) in rats. DL-C), high-density lipoprotein (HDL-C), malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity. Aorta and liver were taken for pathological examination. Results High and low doses of crocetin significantly reduced the serum levels of TC, L DL - C and MDA in rats with atherosclerosis; significantly increased the levels of serum HDL-C, SOD activity and anti-atherosclerosis index (AAI ). The results of pathological sections showed that crocetin significantly reduced atherosclerotic lesions in model rats. Conclusion Crocetin has significant anti-atherosclerotic effects in rats.