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本文检测了163例系统性红斑性狼疮(SLE)、29例皮肤病患者和23例其他胶原病患者血中的脱氧核糖核酸(DNA)。SLE血清及血浆中DNA均高于健康对照组,但血浆与血清DNA含量无明显差别。缓解期患者DNA含量低于活动期患者,但仍高于健康对照组。皮肤病及其他胶原病患者血清DNA均高于健康对照组,但与SLE患者血中DNA含量无明显差别。因此血中DNA含量无诊断的特异性。本文再次证明血中DNA含量与病情有关,DNA含量高者比含量低者预后不佳。作者认为用二苯胺法检测血清DNA有助于观察病情及估计预后。
This article tested deoxyribonucleic acid (DNA) in blood from 163 patients with systemic lupus erythematosus (SLE), 29 skin disease patients and 23 other collagen disease patients. SLE serum and plasma DNA were higher than the healthy control group, but plasma and serum DNA content was no significant difference. Patients with remission of DNA content was lower than active patients, but still higher than the healthy control group. Serum DNA of patients with dermatosis and other collagen diseases was higher than that of healthy controls, but there was no significant difference in DNA content between the patients with SLE and those with SLE. Therefore, the blood DNA content without diagnostic specificity. This article once again proved that the blood DNA content and the disease, DNA content higher than the low content of the poor prognosis. The authors believe that the diphenylamine method to detect serum DNA is helpful to observe the condition and estimate the prognosis.