论文部分内容阅读
目的探讨头颅侧向旋转致脑损伤大鼠模型脑干听觉诱发电位(BAEP)的变化及机制。方法成年大鼠20只,制作头颅瞬间侧向旋转脑损伤模型,测量头颅旋转前及旋转后6h的BAEP,测量电极置于颅顶左侧C2点,左耳予短暂click声刺激,右耳持续予噪声掩蔽,经1000次叠加平均,记录BAEP各波形的潜伏期、波间期和波幅值。结果大鼠头颅旋转后6h和Ⅴ波潜伏期、Ⅰ～Ⅲ和Ⅲ～Ⅴ波波间期明显较旋转前延长,Ⅰ和Ⅴ波波幅较旋转前明显降低,而旋转前后Ⅰ波潜伏期、Ⅰ～Ⅴ波波间期以及Ⅰ波波幅无显著差异。结论头颅瞬间侧向旋转可引起BAEP异常,此与脑干内特殊传导通路的破坏有关,其结构基础为脑干广泛神经轴索损伤。
Objective To investigate the changes and mechanisms of brainstem auditory evoked potential (BAEP) in a rat model of brain injury induced by lateral head rotation. Methods Twenty adult rats were sacrificed and their brains were sacrificed. The BAEP was measured before and 6 hours after craniocerebral rotation. The electrodes were placed on the left C2 of the skull. The left ear was stimulated for a brief click and the right ear continued The noise was masked, and the average latency, wave interval and wave amplitude of each waveform of BAEP were recorded after 1000 overlays. Results After 6h and Ⅴ wave latencies, the durations of Ⅰ ~ Ⅲ and Ⅲ ~ Ⅴ wave durations were longer than those before rotation. The amplitudes of Ⅰ and Ⅴ wave were significantly lower than those before rotation. However, the latency of Ⅰ wave, Ⅰ ~ Ⅴ There was no significant difference between wave duration and wave amplitude. Conclusions The lateral rotation of the skull can cause abnormal BAEP, which is related to the destruction of special conduction pathways in the brainstem. The structural basis is the extensive axonal injury of the brainstem.