细胞凋亡是不同于细胞坏死的细胞自我解体的过程 ,心肌细胞凋亡常见于冠心病 ,细胞凋亡的信号通路有两种途径 :死亡受体和线粒体扩大。凋亡由促凋亡和抗凋亡刺激因素、细胞内凋亡信号激活剂和抑制剂所调节。心肌细胞凋亡的治疗靶标为抑制促凋亡因素、破坏凋亡途径、抑制缺血 再灌注损伤、提高心肌细胞内源性保护机制和瓦解凋亡信号 Apoptosis is different from the process of cell self-disintegration of cell necrosis. Cardiomyocyte apoptosis is common in coronary heart disease. There are two ways of apoptosis signaling pathway: death receptor and mitochondria expansion. Apoptosis is regulated by pro-apoptotic and anti-apoptotic stimuli, intracellular apoptotic signaling activators and inhibitors. Therapeutic targets for cardiomyocyte apoptosis are inhibition of pro-apoptotic factors, destruction of apoptotic pathways, inhibition of ischemia-reperfusion injury, increased cardiomyocyte endogenous protective mechanisms and disruption of apoptotic signals