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目的:探讨不同方法在胃黏膜活检标本中幽门螺杆菌(HP)感染检测中的应用价值。方法:对接受胃镜活检的胃黏膜标本500例分别采用快速尿素酶法、HE染色和免疫组化染色法检测,比较活检组织中HP感染情况。结果:免疫组化检测HP感染的阳性率(56.0%)高于快速尿素酶(33.0%)和HE(30.0%),比较差异显著(P<0.05);与病理诊断结果对照,免疫组化染色检测各胃黏膜病变HP感染存在差异,其中溃疡病HP感染的阳性率最高。结论:免疫组化染色法检测胃黏膜活检标本中HP感染,所获结果准确可靠,值得加以推广。
Objective: To explore the value of different methods in the detection of Helicobacter pylori (HP) infection in gastric mucosa biopsy specimens. Methods: 500 cases of gastric mucosa biopsies were detected by rapid urease method, HE staining and immunohistochemical staining, biopsy tissue HP infection were compared. Results: The positive rate of HP infection detected by immunohistochemistry (56.0%) was higher than that of rapid urease (33.0%) and HE (30.0%) (P <0.05). Compared with pathological diagnosis, immunohistochemistry Detection of gastric mucosal lesions HP infection differences, including the highest rate of HP infection in ulcer disease. Conclusion: The results of immunohistochemical staining for detecting HP infection in gastric biopsy specimens are accurate and reliable and worthy of promotion.