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该研究旨在探讨SD大鼠肝移植W256肿瘤模型的磁共振影像、血管造影征象及相关病理学表现,探索影像学手段在肿瘤研究上的价值。实验采用移植W256瘤块的方法制作20只SD大鼠肝肿瘤模型,移植术后14 d磁共振(MRI)T1加权像(T1WI)、T2加权像(T2WI)、质子加权像(DWI)、增强T1加权像(CE-T1WI)、磁共振灌注成像(T2*PWI)肿瘤形态及功能特征,处死后并做微血管造影与病理组织学检查。结果:MRI检查显示大鼠肝内均可见孤立性结节状肿瘤,肿瘤平均体积为(3 288±516)mm3。病灶T1WI呈低信号,T2WI呈高信号,DWI呈高信号,CE-T1WI病灶信号不均匀增强,中心有无强化区域,T2*PWI显示瘤内血供不及肝脏丰富,分布不均。微血管造影显示肿瘤供血动脉数量和形态分布异常。MRI和微血管造影与病理所见存在良好的相关性。故磁共振结合血管造影是评价肿瘤动物模型及进行肿瘤研究的理想方法。
The purpose of this study was to investigate the magnetic resonance imaging, angiography and related pathological findings of the W256 tumor model of liver transplantation in SD rats and to explore the value of imaging methods in tumor research. Twenty SD rat liver tumor models were made by transplanting W256 tumor lumps. T1WI, T2WI and DWI were performed 14 days after transplantation. T1 weighted images (CE-T1WI), magnetic resonance perfusion imaging (T2 * PWI) tumor morphology and functional characteristics, after death and do microvascular angiography and histopathology. Results: MRI examination showed isolated nodular tumors in the liver of rats, the average tumor volume was (3 288 ± 516) mm3. The lesion showed low signal on T1WI, high signal on T2WI, high signal on DWI, uneven signal on CE-T1WI lesion, and enhancement zone at center. T2 * PWI showed less blood supply on the tumor and less distribution of liver. Microvascular angiography showed abnormalities in the number and morphology of tumor-supplying arteries. There was a good correlation between MRI and angiography and pathology. Therefore, magnetic resonance imaging combined with angiography is an ideal method for tumor model evaluation and tumor research.