论文部分内容阅读
目的探讨高通量血液透析联合左卡尼汀治疗尿毒症心肌病患者的疗效及对其心功能与心肌重构的影响。方法选取2013年3月—2016年2月商丘市中心医院收治的72例尿毒症心肌病患者,根据治疗方式分为两组,各36例。在实施纠正贫血及脂质代谢紊乱、钙磷代谢失衡等治疗的同时,对照组给予高通量血液透析治疗,观察组给予高通量血液透析+左卡尼汀治疗。对比两组治疗前后[左室射血分数(LVEF)、左心室后壁厚度(LVPWD)、左心室舒张末期内径(LVDD)、左室短轴缩短率(FS)、每博心搏量(SV)];并统计两组临床疗效。结果治疗前,两组LVEF、LVPWD、LVDD、FS、SV水平比较,差异无统计学意义(P>0.05),经治疗,观察组LVEF、FS、SV水平高于对照组,LVPWD、LVDD低于对照组,且观察组治疗总有效率94.44%高于对照组77.78%,差异有统计学意义(P<0.05)。结论给予尿毒症心肌病患者高通量血液透析与左卡尼汀联合治疗,可显著提高治疗效果,改善患者心功能,抑制心肌重塑。
Objective To investigate the effect of high-throughput hemodialysis combined with levocarnitine on patients with uremic cardiomyopathy and its influence on cardiac function and myocardial remodeling. Methods Seventy-two patients with uremic cardiomyopathy treated in Shangqiu Central Hospital from March 2013 to February 2016 were divided into two groups according to the treatment mode, 36 cases each. In the implementation of correction of anemia and lipid metabolism disorders, imbalance of calcium and phosphorus metabolism and other treatment, the control group was given high-flux hemodialysis treatment, the observation group was given high-throughput hemodialysis + levocarnitine treatment. The changes of left ventricular ejection fraction (LVEF), left ventricular posterior wall thickness (LVPWD), left ventricular end diastolic diameter (LVDD), left ventricular fractional shortening (FS) )]; And statistics of two groups of clinical efficacy. Results Before treatment, the levels of LVEF, LVPWD, LVDD, FS and SV in the two groups had no significant difference (P> 0.05). After treatment, the levels of LVEF, FS and SV in the observation group were higher than those in the control group, and LVPWD and LVDD were lower than The total effective rate in the observation group was 94.44% higher than that in the control group (77.78%), the difference was statistically significant (P <0.05). Conclusion High-throughput hemodialysis combined with levocarnitine in patients with uremic cardiomyopathy can significantly improve the therapeutic effect, improve cardiac function and inhibit myocardial remodeling.