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用细胞培养方法观察了不同浓度（１０－９～１０－５ｍｏｌ／Ｌ）的全反式维甲酸（ＡＴＲＡ）对正常造血祖细胞集落形成的影响。结果表明，随着浓度的增加，ＡＴＲＡ对红系祖细胞集落形成单位（ＣＦＵ－Ｅ、ＢＦＵ－Ｅ）的抑制作用增加，但在１０－８～１０－６ｍｏｌ／Ｌ内对粒单系祖细胞集落形成单位（ＣＦＵ－ＧＭ）的形成有促进作用，１０－６ｍｏｌ／Ｌ的ＡＴＲＡ对巨核系祖细胞集落形成单位（ＣＦＵ－Ｍｅｇ）生长也有促进作用，提示在急性早幼粒细胞白血病（ＡＰＬ）用ＡＴＲＡ治疗过程中，ＡＴＲＡ参与了其正常造血功能的恢复。
The effects of different concentrations (10-9 to 10-5 mol/L) of all-trans retinoic acid (ATRA) on colony formation of normal hematopoietic progenitor cells were observed by cell culture methods. The results showed that ATRA inhibited the colony-forming units of erythroid progenitor cells (CFU-E, BFU-E) as the concentration increased, but the monophyletic progenitor cells were present in 10-8 to 10-6 mol/L. The formation of colony-forming units (CFU-GM) has a promoting effect, and 10-6 mol/L ATRA also promotes the growth of megakaryocyte progenitor cell colony-forming units (CFU-Meg), suggesting that in acute promyelocytic leukemia (APL) During treatment with ATRA, ATRA participated in the recovery of its normal hematopoietic function.