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本文对２６例缺氧缺血性脑病（ＨＩＥ）新生儿和２８例健康新生儿（对照组）静脉血清肌酸激酶（ＣＫ）、乳酸脱氢酶（ＬＤＨ）、谷草转氨酶（ＧＯＴ）、α－羟丁酸脱氢酶（α－ＨＢＤＨ）于生后３天内进行检测并做心电图以观察ＨＩＥ新生儿心脏受损的情况。结果表明，血清ＣＫ、ＬＤＨ、ＧＯＴ、α－ＨＢＤＨ水平ＨＩＥ组明显高于对照组（ｐ＜０．０１），重度ＨＩＥ组显著高于中度ＨＩＥ组（ｐ＜０．０１），中度ＨＩＥ组高于轻度ＨＩＥ组（ｐ＜０．０１）。ＨＩＥ组异常心电图百分率高于正常对照组，但无统计学差异（ｐ＞０．０５）。提示ＨＩＥ新生儿生后早拥有血清心肌酶活性和心电图的异常改变，似可作为临床早期初步筛查ＨＩＥ新生儿心脏受损及估价其严重程度的指标。
In this study, 26 neonates with hypoxic-ischemic encephalopathy (HIE) and 28 healthy newborns (control group) received serum creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (GOT) Hydroxybutyrate dehydrogenase (α-HBDH) was detected within 3 days after birth and ECG to observe HIE neonatal heart damage. The results showed that serum CK, LDH, GOT and α-HBDH levels in HIE group were significantly higher than those in control group (p <0.01), severe HIE group was significantly higher than that in moderate HIE group (p <0.01) Group was higher than mild HIE group (p <0.01). The percentage of abnormal ECG in HIE group was higher than that in normal control group, but there was no significant difference (p> 0.05). HIE neonatal neonatal early with serum myocardial enzyme activity and ECG abnormalities may be used as a preliminary clinical early neonatal HIE heart damage and assess the severity of indicators.