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虽然氨基糖苷类抗生素和第三代β-内酰肢抗生素对许多病原菌有较强的活性,但由于耐药性日益增多,加之上述药物的毒副作用相对较多,因此需要有新的更有效的药物来满足临床需要。甲氟哌酸是一种新型氟喹诺酮衍生物,具有抗菌谱广、抗菌活性强、作用迅速及半衰期长等特点,特别对肠杆菌和绿脓杆菌有较强的活性。并且具有耐受性好、副作用少、服用方便和与其它抗生素无交叉耐药性等特点。另外,该药有很强的组织渗入力,对脑脊液(CSF)渗入能力较其它和同类抗生素为好。本文主要就与甲氟哌酸治疗中枢神经系统感染有关的文献作一综
Although aminoglycoside antibiotics and third-generation β-lactone antibiotics have strong activity against many pathogens, due to the increasing resistance and the relatively high toxicity and side effects of the above drugs, there is a need for new and more effective Drugs to meet clinical needs. Norfloxacin is a new type of fluoroquinolone derivatives, with broad antibacterial spectrum, strong antibacterial activity, rapid action and long half-life and other characteristics, especially for Enterobacteriaceae and Pseudomonas aeruginosa have strong activity. And has good tolerance, fewer side effects, easy to take and no cross-resistance with other antibiotics and so on. In addition, the drug has a strong tissue infiltration, permeability of cerebrospinal fluid (CSF) better than other antibiotics and similar. This article summarizes the literature related to the treatment of CNS infections with coformuline