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[目的]探讨慢性乙型肝炎(乙肝)患者病情严重程度与血清胆碱酯酶(CHE)的相关性.[方法]测定并比较60例慢性乙肝患者(观察组)、50例同期健康体检正常人员(对照组)血清C H E、透明质酸(H A)、总胆汁酸(TBA)及凝血指标的差异.[结果]乙肝轻度、中度、重度组患者血清CHE、纤维蛋白原(FIB)均显著低于对照组,HA、TBA、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均显著大于对照组,且差异有显著性(P<00.5);血清CHE、FIB水平随慢性乙肝病情加重而降低,HA、TBA随之上升,TT、PT、APTT随之延长,轻度、中度、重度组之间各指标相比较差异均有显著性(P<00.5);Pearson相关分析显示血清CHE与HA、TBA、TT、PT、APTT呈显著负相关(P<0.05),与FIB呈正相关(P<0.05).[结论]血清CHE对慢性乙肝病情严重程度能有效反映,其水平与HA、TBA、凝血四项指标相关.“,”[Objective]To investigate the serum cholinesterase (CHE) in patients with different degrees of chronic hepatitis B (CHB) .[Methods]The serum CHE ,hyaluronic acid (HA) ,total bile acid (TBA) and co-agulation indexes in 60 patients with CHB and 50 healthy persons (control group) were detected .[Results]Levels of serum CHE and fibrinogen (FIB) in patients with mild ,moderate and severe CHB were significantly lower than those in the control group ,while levels of HA ,TBA ,thrombin time (TT) ,prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly higher or longer than those in the control group ,and the difference was significanta ( P <00.5) .Serum CHE and FIB levels decreased with ex-acerbations of chronic hepatitis B ,and HA ,TBA increased ,and TT ,PT ,and APTT were prolonged S.erum CHE and FIB levels decreased with exacerbations of chronic hepatitis B ,and HA ,TBA increased ,and TT , PT ,and APTT were prolonged .Pearson correlation analysis showed that serum CHE was negatively correlated with HA ,TBA ,TT ,PT ,APTT ( P <00.5) ,and positively correlated with FIB ( P <00.5)[.Conclusion]Serum CHE can effectively reflect the severity of CHB ,and its level is related to HA ,TBA and the four inde-xes of coagulation .