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目的探讨金属蛋白酶8(MMP-8)基因C-799T多态性位点与自发性早产遗传易感性的关联性。方法病例组样本包括753例自发性早产(SPTB)新生儿,对照组包括681例足月新生儿。采用最新的Sequenom MassARRAY?SNP检测技术对MMP-8基因C-799T多态性位点进行SNP分型。结果与携带MMP-8基因C-799T多态性位点CC基因型的个体相比,携带至少一个-799T等位型(CT+TT基因型)的个体发生SPTB、合并PROM的SPTB(PPROM)以及轻度早产的风险显著降低。与携带至少一个C等位型(CC+CT基因型)的个体相比,TT基因型与不合并PROM的SPTB的患病风险的降低有临界的相关性。结论 MMP-8基因C-799T多态性位点可以影响SPTB的遗传易感性。
Objective To investigate the association between the polymorphism of C-799T polymorphism of MMP-8 gene and the susceptibility to spontaneous preterm labor. Methods The sample of cases included 753 newborns with spontaneous preterm birth (SPTB) and 681 full-term newborns in the control group. The SNP genotypes of C-799T polymorphism of MMP-8 gene were genotyped using the latest Sequenom MassARRAY ™ SNP detection. Results SPTB, SPTB (PPROM) with PROM were detected in individuals carrying at least one -799T allele (CT + TT genotype) compared with individuals carrying the CC genotype of the C-799T polymorphic site of MMP-8 gene As well as the risk of mild preterm birth is significantly reduced. There was a critical correlation between the TT genotype and the reduced risk of developing SPTB without PROM as compared to individuals carrying at least one C allele (CC + CT genotype). Conclusion The C-799T polymorphism of MMP-8 gene may affect the genetic predisposition of SPTB.