某些元素或化合物能形成两种以上晶体结构即多晶型(Polymorphism)。药物的多晶型现象自六十年代以来方引起国内外重视~[1～3]。现代科学技术的飞跃发展,得以迅速地从现象深入到本质、从宏观深入到微观,现已能从分子水平阐明多晶型的形成原因、结构差异、变化条件及影响等,成为药品生产及研究中不可忽视的一个方面。 Certain elements or compounds can form two or more crystal structures, ie, polymorphism. Polymorphism of drugs has drawn great attention both at home and abroad since the 1960s ~ [1 ~ 3]. The rapid development of modern science and technology can be rapidly from the phenomenon of deep into the essence of macroscopic to micro, from the molecular level can now elucidate the causes of polymorphism, structural differences, changing conditions and effects, as drug production and research In one aspect that can not be ignored.