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根据“运轉型-作用型”假說合成的抗肿瘤药环磷酰胺氮芥(cyclophosphamide,endoxan,cytoxan,癌得星)近年来受到广泛重視。本文报道了京津四单位在1960～1963年間对此药进行的实驗和临床观察,并討論了其临床适应症。第一部分为此药对移植性动物肿瘤的疗效:結果表明,此药对小鼠S-180有显著抑制作用,对艾氏腹水癌細胞形态和分裂数目均有明显影响,小鼠急性LD_(50)和大鼠吉田腹水肉瘤ED_(50)测定表明它的安全系数較大,与国外文献相符。
Cyclophosphamide (cytoxan, cytoxan) has been widely recognized in recent years due to the “run-type” hypothesis. This article reports the experiments and clinical observations of the drug between the 1960s and the 1963s in Beijing and Tianjin, and discusses the clinical indications. The first part is the curative effect of this medicine on the transplanted animal tumor. The results show that this medicine has a significant inhibitory effect on the S-180 of mice and has a significant effect on the cell morphology and division numbers of Ehrlich ascites carcinoma. The acute LD50 ) And rat Yoshida ascites sarcoma ED_ (50) determination showed that its safety factor is larger, consistent with foreign literature.