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一氧化氮(nitric oxide,NO)是一种新发现的细胞信使分子和细胞毒分子,在调节神经系统、心血管系统功能和抗感染免疫方面起重要作用。体内许多细胞如巨噬细胞、血管内皮细胞、平滑肌细胞、白细胞等均有NO合成酶,催化L-精氨酸(L-Arg)生成NO。NO作为活化巨噬细胞的一种细胞毒效应分子,在抑制和杀伤病毒、细菌及真菌的抗感染免疫中起重要作用。IFN-r与IL-2、TNF-α或LPS等可协同诱导巨噬细胞高水平表达NO合成酶(NOS)。在炎症或自身免疫病灶中有大量激活的巨噬细胞,NO与炎症部位的巨噬细胞及中性粒细胞等一起参与了
Nitric oxide (NO) is a newly discovered cell messenger and cytotoxic molecule that plays an important role in regulating the nervous system, cardiovascular system function and anti-infective immunity. Many cells in vivo such as macrophages, vascular endothelial cells, smooth muscle cells, leukocytes, etc. have NO synthase, catalytic L-arginine (L-Arg) to generate NO. NO, a cytotoxic effector molecule that activates macrophages, plays an important role in inhibiting and killing anti-infective immunity of viruses, bacteria and fungi. IFN-r and IL-2, TNF-α or LPS can synergistically induce high levels of NO synthase (NOS) in macrophages. There are a large number of activated macrophages in inflammatory or autoimmune lesions, and NO is involved in inflammation along with macrophages and neutrophils at the site of inflammation