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N-丁苯磺酰胺(NBBS)是一种化学增塑剂,既往被认为对人类无毒。本文作者偶然发现其对动物中枢神经系统有一定毒性。(1)实验选用8～9周雌性新西兰家兔15只,分成5组,每组3只,每月脑池内分别注射NBBS0.1,1,10,50及100 pμ,共4个月。观察较短时间接触NBBS的神经毒性及剂量-反应关系。同时给对照组动物单纯洼射0.9％生理盐水。(2)为观察长期接触NBBS对神经系统的影响,对3组动物(每组6只)脑池内分别注射NBBS 10,50或100 μg,每月一次,共12
N-Butylbenzenesulfonamide (NBBS) is a chemical plasticizer, previously considered non-toxic to humans. The author accidentally found that it has some toxicity to the animal’s central nervous system. (1) Fifteen female New Zealand rabbits (8-9 weeks old) were selected and divided into 5 groups with 3 rats in each group. NBBS0.1, 1, 10, 50 and 100 pμ were injected into the cerebral cistern every month for 4 months. Observe the neurotoxicity and dose-response relationship of NBBS exposure in a short period of time. At the same time to the control group of animals only depression 0.9% saline. (2) To observe the effects of long-term exposure to NBBS on the nervous system, NBBS 10, 50 or 100 μg was injected into the brain pool of 3 animals (6 in each group) once a month for a total of 12