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目的:对肺癌患者和健康人尿液中9种微量元素进行判别分析,为肺癌的早期诊断提供科学依据。方法:用电感耦合等离子体发射光谱法测定肺癌患者和健康人尿液中的铬、铁、锰、铝、镉、铜、锌、镍,用原子荧光光谱法测定硒。结果:各元素线性关系良好,回归系数为0.9990～0.9998,检出限为0.0004～0.03μg·mL-1,方法精密度为1.9%～9.0%,加标回收率为80.1%～120.0%。对肺癌患者和健康人尿液中9种微量元素的含量进行了判别分析,建立判别函数,误判率小于2%。结论:肺癌患者和健康人尿液中9种微量元素的综合水平存在较为显著的差别。
Objective: To discriminate and analyze nine trace elements in urine of healthy people and patients with lung cancer and provide a scientific basis for the early diagnosis of lung cancer. Methods: Chromium, iron, manganese, aluminum, cadmium, copper, zinc and nickel in the urine of patients with lung cancer and healthy people were determined by inductively coupled plasma atomic emission spectrometry. Atomic fluorescence spectrometry was used to determine the content of selenium. Results: The linearity of each element was good, the regression coefficient was 0.9990 ~ 0.9998, the detection limit was 0.0004 ~ 0.03μg · mL-1, the precision was 1.9% -9.0%, and the recoveries were 80.1% -120.0%. The contents of nine trace elements in the urine of patients with lung cancer and healthy people were discriminantly analyzed and the discriminant function was established. The false positive rate was less than 2%. Conclusion: There is a significant difference in the comprehensive levels of nine trace elements in the urine of patients with lung cancer and healthy people.