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目的分析血型为O型的孕妇产前Ig G抗A(B)抗体效价检测情况,以预防新生儿溶血病(HDN)的发生。方法采用微柱凝胶免疫检测技术检测孕妇血浆Ig G抗A(B)效价,并对有妊娠史和不同年龄段的孕妇做Ig G抗体水平比较。结果 741例孕妇中,Ig G抗A(B)效价≥256者177例,占23.9%,共发生HDN 31例;随妊娠次数和妊娠年龄的增加,Ig G抗体效价≥256者的比例和HDN的发病率均升高。结论检测孕妇血浆中Ig G抗A(B)效价有助于早期诊断HDN,指导临床干预措施,预防ABO-HDN的发生。
Objective To analyze the detection of prenatal Ig G anti-A (B) antibody titer in O-pregnant women to prevent neonatal hemolytic disease (HDN). Methods The microcolumn gel immunoassay was used to detect the plasma IgG anti-A (B) titer in pregnant women. Ig G antibody levels in pregnant women with different gestational ages and different ages were compared. Results Of the 741 pregnant women, 177 cases (23.9%) had IgG anti-A (B) titer ≥256, and 31 cases had HDN. With the increase of the number of pregnancy and gestational age, the titer of IgG antibody ≥256 And the incidence of HDN increased. Conclusion Detection of Ig G anti-A (B) titer in plasma of pregnant women is helpful for the early diagnosis of HDN, guiding clinical intervention and preventing the occurrence of ABO-HDN.