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目的研究早期乳腺癌N_(0-1)的临床病理特点。方法回顾分析无锡市妇幼保健院乳腺科2011年1月-2014年12月期间的早期乳腺癌(T_(1-2))N_(0-1)手术病例170例,其中N_1乳腺癌106例,N_0乳腺癌64例,了解早期乳腺癌淋巴结转移的临床和病理特点。结果 N_0与N_1的乳腺癌在发病年龄和HER2、VEGF及Ki-67的表达方面差异无统计学意义(χ~2=0.01,P>0.05;χ~2=0.09,P>0.05;χ~2=0.01,P>0.05;χ~2=1.41,P>0.05);以2 cm为界在N_0和N_1的乳腺癌差异无统计学意义(χ~2=2.42,P>0.05),但肿瘤大小的均值差异有统计学意义(t=3.103,P<0.01);ER,PR和p53阳性表达的乳腺癌在N_1乳腺癌中占比高于N_0乳腺癌,差异有统计学意义(χ~2=9.72,P<0.05;χ~2=5.70,P<0.05;χ~2=6.09,P<0.05);N_1与N_0乳腺癌中的分子亚型构成比例上Luminal B型的比例明显升高,而三阴性乳腺癌的比例减少,差异有统计学意义(χ~2=9.06,P<0.01;χ~2=7.36,P<0.01);早期乳腺癌N_(0-1)激素受体阳性与阳性之间,阴性与阴性之间,在年龄,p53和Ki-67的表达,差异无统计学意义(χ~2=0.44,P>0.05;χ~2=2.96,P>0.05;χ~2=3.37,P>0.05;χ~2=1.07,P>0.05;χ~2=3.35,P>0.05;χ~2=2.04,P>0.05);早期激素受体阳性乳腺癌之间N_0与N_1相比,阳性与阴性乳腺癌相比,肿瘤大小差异有统计学意义(χ~2=5.09,P<0.05;χ~2=4.09,P<0.05),但激素受体阴性之间N_0与N_1相比肿瘤大小差异无统计学意义(χ~2=0.45,P>0.05);激素受体阳性和阴性乳腺癌之间Ki-67的表达,相比差异有统计学意义(χ~2=10.28,P<0.01)。结论激素受体阳性的乳腺癌,尤其是Luminal B型较激素受体阴性的乳腺癌更容易发生早期淋巴结的转移,而且肿瘤的大小和p53的阳性表达可能促进乳腺癌的早期转移,Ki-67在激素受体阴性乳腺癌中高表达。
Objective To study the clinicopathological features of early breast cancer N_ (0-1). Methods A retrospective analysis of Wuxi MCH maternity department from January 2011 to December 2014 period of early breast cancer (T_ (1-2)) N_ (0-1) surgical cases of 170 cases, including N_1 breast cancer in 106 cases, N_0 breast cancer in 64 cases, to understand the clinical and pathological features of lymph node metastasis in early breast cancer. Results There was no significant difference in the age of onset and the expression of HER2, VEGF and Ki-67 between N_0 and N_1 breast cancer (χ ~ 2 = 0.01, P> 0.05; χ ~ 2 = 0.09, P> 0.05; = 0.01, P> 0.05; χ ~ 2 = 1.41, P> 0.05). There was no significant difference in breast cancer between N_0 and N_1 with 2 cm boundary (χ ~ 2 = (T = 3.103, P <0.01). The positive rates of ER, PR and p53 in N 1 breast cancer were higher than those in N 0 breast cancer (χ ~ 2 = 9.72, P <0.05; χ ~ 2 = 5.70, P <0.05; χ ~ 2 = 6.09, P <0.05); while the proportion of Luminal B in N 1 and N 0 breast cancer cells was significantly increased The proportion of triple-negative breast cancer decreased, the difference was statistically significant (χ ~ 2 = 9.06, P <0.01; χ ~ 2 = 7.36, P <0.01); early breast cancer N_ (0-1) hormone receptor positive and positive There was no significant difference in the expression of p53, Ki-67 between the negative and negative groups (χ ~ 2 = 0.44, P> 0.05; 3.37, P> 0.05; χ ~ 2 = 1.07, P> 0.05; χ ~ 2 = 3.35, P> 0.05; χ ~ 2 = 2.04, P> 0.05); early hormone receptor positive breast cancer N_0 and N_1 phase Compared to positive and negative breast cancer, there are differences in tumor size Statistical significance (χ ~ 2 = 5.09, P <0.05; χ ~ 2 = 4.09, P <0.05), but there was no significant difference in the size of tumor between N_0 and N_1 , P> 0.05). There was significant difference in the expression of Ki-67 between hormone receptor positive and negative breast cancer (χ ~ 2 = 10.28, P <0.01). Conclusions Hormone receptor positive breast cancer, especially Luminal B type, is more likely to have early lymph node metastasis than breast cancer, and the size of the tumor and the positive expression of p53 may promote the early metastasis of breast cancer. Ki-67 High expression in hormone receptor negative breast cancer.