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目的：探讨喉鳞状细胞癌中ＨＰＶ感染和ｐ１６ 表达的情况及临床相关性。方法：用免疫组化和原位杂交的方法对５２ 例喉鳞癌组织中ＨＰＶ 感染和ｐ１６ 的表达情况进行检测。结果：ＨＰＶ感染的阳性率为６１－５４ ％（３２／５２） ，ｐ１６ 的阳性率为４４－２３ ％（２３／５２）。结论：ＨＰＶ 感染与ｐ１６ 的表达有关；ＨＰＶ 感染与临床分期、癌细胞的分化程度、肿瘤的淋巴结转移情况、临床分型无关；ｐ１６ 的表达与癌细胞的分化程度、肿瘤的颈淋巴结转移情况有关，与临床分型、分期无关。
Objective: To investigate the status and clinical significance of HPV infection and p16 expression in laryngeal squamous cell carcinoma. Methods: HPV infection and p16 expression in 52 cases of laryngeal squamous cell carcinoma were detected by immunohistochemistry and in situ hybridization. Results: The positive rate of HPV infection was 61-54% (32/52), and the positive rate of p16 was 44-23% (23/52). Conclusion: The HPV infection is related to the expression of p16. The HPV infection is not associated with the clinical stage, the differentiation of cancer cells, the lymph node metastasis and the clinical classification of the tumor. The expression of p16 is related to the differentiation of the cancer cells and the metastasis of cervical lymph nodes , And clinical classification, stage has nothing to do.